Denver, February 20: HIV (human immunodeficiency virus) a virus that attacks the body’s immune system has been known to have no cure. However, a patient living with HIV who received a blood stem cell transplant for high-risk acute myeloid leukaemia has been free of the virus for 14 months after stopping HIV antiretroviral drug treatment, suggesting a cure, according to the Weill Cornell Medicine physician-scientists.
They were the ones who performed the transplant and managed her care. The new case of long-term HIV remission was reported at the 29th annual ‘Conference on Retroviruses and Opportunistic Infections’, in Denver.
As in two other successful cases that have been reported, the transplanted donor cells bore a mutation that makes them resistant to HIV infection. The patient received transplants of blood- and immune-cell replenishing stem cells after having her own blood cell population, including leukemic cells, destroyed by high-dose chemotherapy. Woman Cured of HIV! Leukaemia Patient in US Becomes First Woman To Be Cured of HIV Using Stem Cell Transplant, Says Report.
The transplanted cells came from two sources: stem cells from a healthy adult relative were used to quickly restore her blood cell population to reduce infectious complications, and umbilical cord blood from an unrelated newborn child was used to provide long-term blood reconstitution.
Cord blood is used to supply blood stem cells for transplants for patients unable to find matched adult donors. Transplant specialists have found that cord blood may be used successfully even when they come from an unrelated donor whose immune markers only partially match the recipient’s.
Doctors, in this case, used cord blood containing an HIV-resistance gene variant called CCR5D32. HIV normally uses the CCR5 co-receptor to help it infect immune cells, but the receptor’s D32 variant effectively blocks viral entry.
Three months after the transplant, tests showed that the patient’s blood cell population was entirely derived from the HIV-resistant cord blood cells. Post-transplant studies could no longer detect HIV by various sensitive assays. The patient eventually stopped taking antiretroviral drugs to suppress her HIV infection, and so far, has been off the HIV drugs for 14 months, with no signs of HIV re-emergence after close follow-up during COVID 19 pandemic–indicating a likely cure, although physicians at this stage prefer to call it long-term remission.
She has also been leukaemia-free for more than four years. Two prior cases of long-term remission in HIV-positive cancer patients after adult CCR5D32 stem cell transplantation have been reported. This case is the first to use cord blood cells, and the first to treat a woman and someone who identifies as mixed-race. Since the CCR5D32 variant is much more common in people of European heritage, it is harder to find well-matched CCR5D32 donors for traditional stem cell transplants into nonwhite patients, although the use of cord blood partly alleviates this problem.
Stem cell transplant specialists Dr. Jingmei Hsu and Dr. Koen Van Besien and infectious disease specialist Dr. Marshall Glesby were the physician-scientists who led the NIH-funded clinical trial at Weill Cornell Medicine in collaboration with investigators at the University of California Los Angeles, Johns Hopkins University School of Medicine and several other institutions.
The investigators concluded that cord blood containing the CCR5D32 variant offers a possible cure for both haematological malignancies and HIV and should be considered as a stem cell source when HIV-positive cancer patients need blood stem cell transplants. However, the procedure is considered too risky for HIV-positive patients who otherwise don’t need such transplants.
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